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A convenient preparative method for anionic tris(substituted pyrazolyl)methane ligands

✍ Scribed by Loı̈c J. Charbonnière; Raymond Ziessel

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
98 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of tris [3-(6-carboxypyridin-2-yl)pyrazol-1-yl]methane is described in a linear multi-step protocol. The pyridyl-pyrazolyl arms are first constructed before being condensed with chloroform. Careful study of the condensation reaction shows the presence of an isomeric form of the tris(pyrazolyl)methane derivative in which one of the pyrazolyl substituents is linked through the nitrogen atom at the 2 position of the pyrazol. After acid-catalysed isomerisation to the desired isomer, the intermediate compound was subjected to a carboalkoxylation reaction and a subsequent hydrolysis. These are some rare examples of reactions directly occurring on the tris(pyrazolyl)methane platforms.

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