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A convenient preparation of 3-methyl-3,4-dihydro-2(1H)-quinazolinone

✍ Scribed by Frederick A. Golec Jr.; Laurence W. Reilly Jr.

Book ID
112128927
Publisher
Journal of Heterocyclic Chemistry
Year
1988
Tongue
English
Weight
150 KB
Volume
25
Category
Article
ISSN
0022-152X

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## Abstract The ureas **3** which are obtained from 3‐(benzylamino)propanenitrile (**1**) and various isocyanates (**2**) cyclize readily upon heating in ethanol, in the presence of hydrochloric acid, to form 3‐substituted 1‐benzyldihydro‐2,4‐(1__H__,3__H__)pyrimidinediones (**11**) in good yield.