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A convenient preparation of 1,3-disubstituted dihydro-2,4-(1H,3H)pyrimidinediones

✍ Scribed by L. M. Deck; E. P. Papadopoulos


Publisher
Journal of Heterocyclic Chemistry
Year
2000
Tongue
English
Weight
313 KB
Volume
37
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

The ureas 3 which are obtained from 3‐(benzylamino)propanenitrile (1) and various isocyanates (2) cyclize readily upon heating in ethanol, in the presence of hydrochloric acid, to form 3‐substituted 1‐benzyldihydro‐2,4‐(1__H__,3__H__)pyrimidinediones (11) in good yield.


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