A convenient method for the synthesis of norstatine derivatives fromN-Fmoc orN-Boc amino acids

✍ Scribed by Saïd Kourtal; Joëlle Paris

• Book ID: 104632113
• Publisher: Springer Netherlands
• Year: 1996
• Tongue: English
• Weight: 360 KB
• Volume: 3
• Category: Article
• ISSN: 1573-3149
• DOI: 10.1007/bf00126736

✦ Synopsis

A new and convenient method for synthesizing norstatine derivatives has been developed. The key step is the preparation of propargylic alcohols from N-Fmoc or N-Boc amino aldehydes, followed by transformation to carboxylic acids after protection of the alcohols. The N-Boc-protected derivatives are coupled to a dipeptide sequence to afford peptide mimetics (norstatines).