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A convenient method for the synthesis of 3,5,7-trimethoxy-2-phenyl-4-quinolones

✍ Scribed by Chantal Beney; Mohamed Hadjeri; Anne-Marie Mariotte; Ahcène Boumendjel


Book ID
104210793
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
129 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis


The synthesis of 2-aryl-3,5,7-trimethoxy-4-quinolones was accomplished in three steps starting from 3,5dimethoxyaniline and an aroyl chloride. These structures might be used as potential ¯avonol analogs.


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## Abstract Condensation of 2‐hydroxyacetophenone with benzaldehyde in the presence of 70% perchloric acid in ethyl orthoformate gave the corresponding 4‐ethoxyflavylium perchlorate, which was treated with aqueous ammonia or methylamine solution to afford 1,6,7,8‐substituted 2‐(3′,4′‐substituted‐ph