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A convenient, efficient method for conjugate reductions using catalytic quantities of Cu(I)

✍ Scribed by Bruce H. Lipshutz; John Keith; Patrick Papa; Randall Vivian

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
202 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

Addition reactions to c~,13-unsaturated carbonyl derivatives, 1 in particular with nonstabilized nucleophiles, remains primarily associated with organocopper chemistry. 2 Within this realm lies the unique potential for conjugate hydride delivery, which not only adds flexibility for arriving at a given target, but also provides an attractive entry to products of inverted stereochemistry (Scheme 1).

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✍ Iwao Ojima; Tetsuo Kogure; Yoichiro Nagai πŸ“‚ Article πŸ“… 1973 πŸ› Elsevier Science 🌐 French βš– 195 KB

The reduction of Schlff bases to form secondary amines has been accomplished by catalytic hydrogenatzon' and by various reagents such as maqneslum in 3 methano12, LiAlH4 , 4 and NaBH4 . More recently, [Fe3(C0)12] was reported to effective for the reaction 5 . We found that the reduction of various c