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A convenient approach to cyclic enol phosphates via ring-closing metathesis

โœ Scribed by Alan Whitehead; Joel D. Moore; Paul R. Hanson

Book ID
104253618
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
81 KB
Volume
44
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A strategy employing the second generation Grubbs catalyst in order to facilitate the generation of a variety of cyclic enol phosphates, including 2H-chromen-4-yl, 1,2-dihydroquinolin-4-yl, 2H-thiochromen-4-yl, 2H-thiochromen-4-yl 1,1-dioxide, and benzofuran-2-yl enol phosphate scaffolds is described. This work represents the first case of an olefin metathesis reaction in which one of the groups participating in the metathesis event is an enol phosphate moiety.

๐Ÿ“œ SIMILAR VOLUMES

Cyclic sulfonamides via the ring-closing
Cyclic sulfonamides via the ring-closing metathesis reaction
โœ Paul R. Hanson; Donald A. Probst; Randall E. Robinson; Mei Yau ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 244 KB

The first examples of ring-closing metathesis (RCM) reactions on allyl-and vinylsulfonamide templates 1 and 2 catalyzed by the Grubbs ruthenium alkylidene 3 are described. The rate of cyclization of these reactions are sensitive to simple olefin substitution. These RCM reactions yield novel cyclic a