## Abstract magnified image In a search for cytotoxic fluorescent materials a series of N‐alkylated and N,N‐dialkylated 3,5‐bis(arylidene)piperidones was synthesized. Alkylation of 3,5‐bis(arylidene)‐4‐piperidone afforded quaternary salts only while condensation of N‐alkyl‐4‐piperidones with subst
A Conformational and Structure−Activity Relationship Study of Cytotoxic 3,5-Bis(arylidene)-4-piperidones and Related N -Acryloyl Analogues
✍ Scribed by Dimmock, Jonathan R.; Padmanilayam, Maniyan P.; Puthucode, Ramanan N.; Nazarali, Adil J.; Motaganahalli, Narasimhan L.; Zello, Gordon A.; Quail, J. Wilson; Oloo, Eliud O.; Kraatz, Heinz-Bernhard; Prisciak, Jared S.; Allen, Theresa M.; Santos, Cheryl L.; Balzarini, Jan; De Clercq, Erik; Manavathu, Elias K.
- Book ID
- 120519196
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 84 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-2623
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📜 SIMILAR VOLUMES
In a search for cytotoxic fluorescent ma- terials, a series of N-phosphorylated compounds 2a-c were prepared by phosphorylation of 3,5-bis(4-N,Ndimethylbenzylidene)-4-piperidone 1. According to X-ray investigations, molecule 2a is E,E-isomer with axial position of the P(O)(OCH 2 CF 3 ) 2 substituent