𝔖 Bobbio Scriptorium
✦   LIBER   ✦

N-phosphorylated 3,5-bis(arylidene)4-piperidones: Synthesis, X-ray structure, and evaluation of antitumor activity

✍ Scribed by Irina L. Odinets; Oleg I. Artyushin; Evgenii I. Goryunov; Konstantin A. Lyssenko; Ekaterina Yu. Rybalkina; Ilya V. Kosilkin; Tatiana V. Timofeeva; Mikhail Yu. Antipin

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
123 KB
Volume
16
Category
Article
ISSN
1042-7163

No coin nor oath required. For personal study only.

✦ Synopsis

In a search for cytotoxic fluorescent ma- terials, a series of N-phosphorylated compounds 2a-c were prepared by phosphorylation of 3,5-bis(4-N,Ndimethylbenzylidene)-4-piperidone 1. According to X-ray investigations, molecule 2a is E,E-isomer with axial position of the P(O)(OCH 2 CF 3 ) 2 substituent. Fluorescence of compounds 2a-c was found to be similar to fluorescence of nonphosphorylated compound 1. The cytotoxicity of the compounds 2a-c was estimated on several human tumor cell lines (H9, K562, and MCF7).

πŸ“œ SIMILAR VOLUMES

N-alkylated 3,5-bis(arylidene)-4-piperid
N-alkylated 3,5-bis(arylidene)-4-piperidones. Synthetic approaches, X-ray structure and anticancer activity
✍ Michael V. Makarov; Irina L. Odinets; Konstantin A. Lyssenko; Ekaterina Yu. Ryba πŸ“‚ Article πŸ“… 2008 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 417 KB

## Abstract magnified image In a search for cytotoxic fluorescent materials a series of N‐alkylated and N,N‐dialkylated 3,5‐bis(arylidene)piperidones was synthesized. Alkylation of 3,5‐bis(arylidene)‐4‐piperidone afforded quaternary salts only while condensation of N‐alkyl‐4‐piperidones with subst

N-phosphinyl ureas: Synthesis, character
N-phosphinyl ureas: Synthesis, characterization, X-ray structure, and in vitro evaluation of antitumor activity
✍ Khodayar Gholivand; Nilufar Dorosti; Fatemeh Ghaziany; Manouchehr Mirshahi; Sina πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 335 KB πŸ‘ 2 views

A new series of N-phosphinylureas 5b, 6a-7c was synthesized and characterized by 1 H, 13 C, 31 P NMR, IR, and elemental analysis. The three-dimensional structure of 5b has been determined by X-ray crystallography. The crystal structure revealed the existence of four independent molecules. All struct

Synthesis, X-Ray Crystallographic Analys
Synthesis, X-Ray Crystallographic Analysis and Antitumor Activity of 3,6-Bis(substitutedphenyl)-1,4-bis (substitutedphenylsulfonyl)-1,4-dihydro-1,2,4,5-tetrazine.
✍ Wei-Xiao Hu; Lu-ping Lv; Feng Xu; Hai-Bo Shi πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons βš– 15 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

ChemInform Abstract: Synthesis of 3,4-Bi
ChemInform Abstract: Synthesis of 3,4-Bis(fluorenylidene)-5- (4-fluorophenylcyanomethylene)tetrahydrofuran-2-one and the X-Ray Structure of Its Cyclized Form.
✍ Shar S. Al-Shihry πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons βš– 29 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v