A concise synthesis of a promising protein kinase C inhibitor: D-erythro-sphingosine
β Scribed by Van-Thoai Pham; Jae-Eun Joo; Yong-Shou Tian; Chang-Young Oh; Won-Hun Ham
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 497 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0253-6269
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
D-erythro-Sphingosine (1) and D-erythro -2-azidosphingosine (2) are both prepared from commercially available and cheap D-ribo -phytosphingosine (3) in a yield of 58% and 70%, respectively. A key transformation in the synthesis of D-erythro -sphingosine (1) is the palladium catalyzed regiospecific r
## Abstract Two stereoisomers of penazetidine A (1a), the azetidine alkaloid isolated from the IndoβPacific marine sponge __Penares sollasi__, were synthesized by starting from (__S__)βserine and (__R__)βor (__S__)βcitronellol. The natural penazetidine A must be either (2__S__,3__R__,4__S__,12β²__R_