𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A concise route to the right wing of ciguatoxin

✍ Scribed by Atsushi Tatami; Masayuki Inoue; Hisatoshi Uehara; Masahiro Hirama

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
302 KB
Volume
44
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

A concise route to the HIJKLM-ring fragment 10 of ciguatoxin (CTX) and 51-hydroxyCTX3C was developed in which oxiranyl anion addition and intramolecular carbonyl olefination were utilized as key transformations. The present procedure requires only 23 steps from the I-ring 5, while 35 steps were employed in a previous synthesis of the corresponding right wing 11 of CTX3C. The high efficiency of the present synthesis ensures a supply of 10 for total synthesis and biomedical applications.

πŸ“œ SIMILAR VOLUMES

A Concise Route to the Right Wing of Cig
A Concise Route to the Right Wing of Ciguatoxin.
✍ Atsushi Tatami; Masayuki Inoue; Hisatoshi Uehara; Masahiro Hirama πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons βš– 70 KB πŸ‘ 2 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

A Concise Route to Two Distinct E-Ring S
A Concise Route to Two Distinct E-Ring Structures of Ciguatoxins.
✍ Masayuki Inoue; Masafumi Iwatsu; Shuji Yamashita; Masahiro Hirama πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons βš– 22 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Expeditious tandem-metathesis route to t
Expeditious tandem-metathesis route to the AB-ring fragment of ciguatoxin
✍ Hiroki Oguri; Shin-ya Sasaki; Tohru Oishi; Masahiro Hirama πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 231 KB

The AB-ring fragment of ciguatoxin was synthesized in ten steps from tri-O-benzyl-D-glucal based on a highly diastereoselective ring-closing metathesis and subsequent cross metathesis.