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Expeditious tandem-metathesis route to the AB-ring fragment of ciguatoxin

✍ Scribed by Hiroki Oguri; Shin-ya Sasaki; Tohru Oishi; Masahiro Hirama

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 231 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01017-5

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✦ Synopsis

The AB-ring fragment of ciguatoxin was synthesized in ten steps from tri-O-benzyl-D-glucal based on a highly diastereoselective ring-closing metathesis and subsequent cross metathesis.

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