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A concise formal synthesis of luotonin A

✍ Scribed by Daire Osborne; Paul J Stevenson

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 59 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)01049-3

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✦ Synopsis

N-Acetyl-2-azetine undergoes Lewis acid catalysed [4+2] cycloaddition fragmentation reactions with imines derived from aniline to give 2,3-disubstituted quinolines. This chemistry was extended to a 2-glyoxylate imine to give rapid access to an advanced precursor to the antitumour alkaloid luotonin A.

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