A concise synthesis of (±)-methylenolactocin and the formal synthesis of (±)-phaseolinic acid
✍ Scribed by Teck-Peng Loh; Pek-Ling Lye
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 96 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
±)-Methylenolactocin was prepared in five steps involving an indium-mediated allylation reaction as the key step.
📜 SIMILAR VOLUMES
N-Acetyl-2-azetine undergoes Lewis acid catalysed [4+2] cycloaddition fragmentation reactions with imines derived from aniline to give 2,3-disubstituted quinolines. This chemistry was extended to a 2-glyoxylate imine to give rapid access to an advanced precursor to the antitumour alkaloid luotonin A
Dedicated to Professor Dieter Seebach for his formidable and communicative enthusiasm for chemistry The formal syntheses of (AE)-nephromopsinic acid, (À)-phaseolinic acid, and the first total synthesis of (À)dihydropertusaric acid from (AE)-and (À)-7-oxabicyclo[2.2.1]hept-5-en-2-one are described.