The selection of medium feed rates for perfusion bioreactors represents a challenge for process optimization, particularly in bioreactors that are sampled infrequently. When the present and immediate future of a bioprocess can be adequately described, predictive control can minimize deviations from
A comparison of three different mammalian cell bioreactors for the production of monoclonal antibodies
โ Scribed by B. Persson; C. Emborg
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 653 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1615-7605
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A major variable to consider in the production of biologicals from mammalian cell cultures is the mode of operation, be it a batch, continuous, perfusion, fed-batch or other production method. The final choice must consider a number of fundamental and economic issues. Here we present some antibody p
An Enzyme Linked Immuno Sorbent Assays (ELISA) and an Electro-chemiluminescent Immuno Assay (CIA) are compared for the purpose of monitoring product formation in mammalian cell bioreactors. The ELISA had a relative standard deviation of 10%, compared to 8% for the CIA. The CIA was found to be a fast