Performance of an external loop air-lift bioreactor for the production of monoclonal antibodies by immobilized hybridoma cells

Effect of serum concentration on hybrido

Effect of serum concentration on hybridoma viable cell density and production of monoclonal antibodies in cstrs and on shear sensitivity in air-lift loop reactors

✍ D. E. Martens; E. C. Beuvery; C. D. De Gooijer; J. Tramper 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 688 KB

The death rate of hybridoma cells, grown in a continuous culture, has been studied in a small air-lift loop reactor as a function of reactor height and injected gas flow rate. The first-order death-rate constant was found to be proportional to the reciprocal height and to the gas flow rate, in accor