Investigations in animals have suggested that conjugation of paracetamol may be reduced in malaria. We have measured plasma concentrations and the urinary excretion of paracetamol and its phase II metabolites in eight Thai patients during uncomplicated falciparum malaria and in convalescence, follow
A comparison of the pharmacokinetics of mefloquine in healthy Thai volunteers and in Thai patients with falciparum malaria
โ Scribed by J. Karbwang; D. J. Back; D. Bunnag; A. M. Breckenridge
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 390 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0031-6970
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๐ SIMILAR VOLUMES
The pharmacokinetics and tolerance of a 4.5 gm 7&y halofantrine loading dose regimen were evaluated in 10 Thai patients with malaria and in 10 noninfected volunteers. Halofantrine peak plasma concentrations and bioavailability on the first day of treatment were significantly lower in patients with m
Objectives: To determine the effect of reduced hepatic function on the pharmacokinetics of minoxidil. The pharmacokinetics of antipyrine, lorazepam, and indocyanine green were included as indicators of hepatic function. Methods: Eight mild cirrhotics and eight healthy subjects received antipyrine (p