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Paracetamol disposition in Thai patients during and after treatment of falciparum malaria

✍ Scribed by S. Ismail; D. J. Back; G. Edwards; K. Na Bangchang; J. Karbwang

Publisher
Springer
Year
1995
Tongue
English
Weight
464 KB
Volume
48
Category
Article
ISSN
0031-6970

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✦ Synopsis

Investigations in animals have suggested that conjugation of paracetamol may be reduced in malaria. We have measured plasma concentrations and the urinary excretion of paracetamol and its phase II metabolites in eight Thai patients during uncomplicated falciparum malaria and in convalescence, following a 1000 mg single oral dose.

The apparent oral clearance (Malaria, 3.6; Convalescence, 3.9; ml. min -1. kg-1), the elimination half-life (Malaria, 3.8; Convalescence, 3.7 h) and apparent volume of distribution (Malaria, 1.2; Convalescence, 1.2; 1. kg -1) of paracetamol were similar during malaria and convalescence. In addition, the urinary excretion of paracetamol and its major phase II metabolites and their formation clearances from paracetamol were not significantly different between the two study phases.

These data show that clinical malaria infection has no effect on the conjugation of paracetamol in man.

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