A chemoenzymatic synthesis of leukotriene B4
β Scribed by Han, Chao Qi; DiTullio, Dennis; Wang, Yi Fong; Sih, Charles J.
- Book ID
- 126254917
- Publisher
- American Chemical Society
- Year
- 1986
- Tongue
- English
- Weight
- 916 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0022-3263
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A stereospecific and chorally economical synthesis of LTE, starting from E-deoxy-D-nbose IS reported as part of a comprehensive and efflclent approach to the Leukotnenes (A, 8, C, 0, E). The process includes a novel approach to choral dienlc synthons. Leukotnene 8, (1) IS a component of the arachldo
## Abstract Incubation of [14,15,17,17,18,18β^2^H~6~] leukotriene A~4~ obtained by hydrolysis of chiral [14,15,17,17,18,18β^2^H~6~] leukotriene A~4~ methylester with human monocytes resulted in the formation of [14,15,17,17,18,18β^2^H~6~] leukotriene B~4~ (d~6~βLTB~4~) and its trans isomers 6βtrans