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A chemoenzymatic and enantioselective total synthesis of the resorcylic acid lactone L-783,290, the trans-isomer of L-783,277

✍ Scribed by Andrew Lin; Anthony C. Willis; Martin G. Banwell

Book ID: 104097270
Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 516 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.12.067

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✦ Synopsis

The structure, 5, assigned to the resorcylic acid lactone L-783,290 has been prepared for the first time and in a modular fashion using a Heck reaction to link the readily available fragments 8 and 14. Chemoenzymatic methods were used to prepare the latter fragment, in enantiopure form, from chlorobenzene.

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