A chemo- and regio-selective three-component dihydropyrimidinone synthesis
β Scribed by Bailey, Chris D.; Houlden, Chris E.; Bar, Gr?gory L. J.; Lloyd-Jones, Guy C.; Booker-Milburn, Kevin I.
- Book ID
- 120864828
- Publisher
- Royal Society of Chemistry
- Year
- 2007
- Tongue
- English
- Weight
- 224 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1359-7345
- DOI
- 10.1039/B707361E
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Optimily active allylic sulphidcd 10-13, bearing two difiuent leaving groups. at with orgsnocoppet reagents by selective salwtitalioa of the hetemcyclic moiety leading to opdcally active homoallylic pivalates with cbemo-. regie aad enaatiocaotrd.This~~ivity~toberelatedtathecooldirmtionexatadbythehet
The synthesis of dihydropyrimidinones via a clean multi-component Biginelli reaction under microwave irradiation is reported. The copper-catalyzed process proved to be simple, efficient, economical, and environmentally friendly.