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A Chaperone Cascade Sorts Proteins for Posttranslational Membrane Insertion into the Endoplasmic Reticulum

✍ Scribed by Fei Wang; Emily C. Brown; Gary Mak; Jimmy Zhuang; Vladimir Denic

Book ID
116754935
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
870 KB
Volume
40
Category
Article
ISSN
1097-2765

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The synthesis of biological membranes requires the insertion of proteins into a lipid bilayer. The rough endoplasmic reticulum of eukaryotic cells is a principal site of membrane biogenesis. The insertion of proteins into the membrane of the endoplasmic reticulum is mediated by a resident proteinace