The genetic determinants for most breast cancer cases remain elusive. However, a mutation in a tumor suppressor gene, such as p53, BRCA1, BRCA2, or ATM, has been determined to be one mechanism of breast carcinogenesis. It has been established that inherited mutations in p53, BRCA1, and BRCA2 signifi
A case for human tumor-suppressor genes
β Scribed by Eric J. Stanbridge
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 581 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
β¦ Synopsis
Effect of X-ray induced DNA damage on DNAase I hypersensitivity of SV 40 chromatin: relation to elastic torsional strain in DNA. Nucl. Acih Rex (In the Press.) 25 MARTINSON, H. G. (1985). Personal communication. 26 GROSSCHEDL, R. & BIRNSTIEL, M. L. (1980). Spacer DNA sequences upstream of the TATAAATA sequence are essential for promotion ofH2A histone gene transcription
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Background: Brain tumors claimed the lives of 13,300 people in 1995. Our objective was to isolate and characterize unique tumor-suppressor genes from human brain tumors derived from patients in the United States. Methods: Differential display-polymerase chain reaction was used to isolate tumor suppr
## Abstract We have previously described a functional model for identification of human liver tumor suppressor genes in which human chromosome 11 was introduced into rat liver epithelial tumor cell lines via microcellβmediated chromosome transfer, producing microcell hybrid (MCH) cell lines that ex