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A biomimetic chemical synthesis of humulene from farnesol

✍ Scribed by E.J. Corey; Sylvain Daigneault; Brian R. Dixon

Publisher: Elsevier Science
Year: 1993
Tongue: French
Weight: 259 KB
Volume: 34
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)79198-2

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✦ Synopsis

The first synthesis of humulene (1) by a biomimetic cation-olefin cyclization route is reported.

Although several syntheses of the structurally interesting cyclic ttiene humulene (1) have been devel-1 the direct formation of this sesquiqne iiom its biogenetic pmcmsor E&famesol has never been mported despite the ready availability of fames01 and the extensive studies of its chemistry. Indeed, it is clear

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