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A biochemical analysis of topoisomerase II α and β kinase activity found in HIV-1 infected cells and virus

✍ Scribed by Anand K. Kondapi; Gade Padmaja; N. Satyanarayana; Robin Mukhopadyaya; Marvin S. Reitz


Book ID
116177400
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
882 KB
Volume
441
Category
Article
ISSN
0003-9861

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In the human immunodeficiency virus type 1 (HIV-1)-infected brain, the virus does not replicate in astrocytes, but a synthesis of viral regulatory proteins occurs in these cells, leading to accumulation of Nef. As an approach to understand the effects of Nef on astrocyte functional activity, we anal