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Extracellular HIV-1 Tat Protein Induces a Rapid and Selective Activation of Protein Kinase C (PKC)-α, -ϵ, and -ζ Isoforms in PC12 Cells

✍ Scribed by Paola Borgatti; Giorgio Zauli; Lewis C. Cantley; Silvano Capitani


Book ID
115581373
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
383 KB
Volume
242
Category
Article
ISSN
0006-291X

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In the human immunodeficiency virus type 1 (HIV-1)-infected brain, the virus does not replicate in astrocytes, but a synthesis of viral regulatory proteins occurs in these cells, leading to accumulation of Nef. As an approach to understand the effects of Nef on astrocyte functional activity, we anal