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Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1β and TNF-α induced production of inflammatory mediators

✍ Scribed by Andreas Billich; Frédéric Bornancin; Diana Mechtcheriakova; François Natt; Dieter Huesken; Thomas Baumruker

Book ID
113527744
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
207 KB
Volume
17
Category
Article
ISSN
0898-6568

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## Abstract Breakdown of the extracellular matrix (ECM) is accomplished by the concerted action of several proteases, including the urokinase plasminogen‐activator (uPA) system and matrix metalloproteinases (MMPs), which is crucial for cancer invasion and metastasis. Several reports have shown that