SPECT imaging of the α4β2 nicotinic rece
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Sally L. Pimlott; Margaret Piggott; James Patterson; Jonathan Cavanagh; David J.
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Article
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2007
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John Wiley and Sons
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French
⚖ 153 KB
## Abstract In order to image nAChR density __in vivo__ in humans, [5‐^123^I]‐iodo‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine ([5‐^123^I]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, __in vitro__ validation in human post‐mortem tissue and some in