A 10-step, asymmetric synthesis of (S)-camptothecin
β Scribed by Comins, Daniel L.; Baevsky, Matthew F.; Hong, Hao
- Book ID
- 119945060
- Publisher
- American Chemical Society
- Year
- 1992
- Tongue
- English
- Weight
- 250 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0002-7863
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π SIMILAR VOLUMES
## Abstract A sixβstep asymmetric total synthesis of (20__S__)βcamptothecin (**1**) has been accomplished in 25% overall yield starting from the known pyridone **3**. The key steps in this synthesis are the chemoselective Niβcatalyzed hydrogenation of 3βcyanopyridone **6** to 3βformylpyridone **7**
## Abstract The synthesis is given for three ring A tritiated camptothecin (CPT) analogs as biological probes in the study of the parent compounds which are of current widespread interest as potent anticancer agents. The strategy of catalytic tritolysis of aryl halide bonds was employed, and thus t