## Abstract The synthesis of the title compounds [^14^C]‐PMEG (5) and [^14^c]‐EPMG (6) are described. Treatment of [^14^C]guanine with acetic anhydride in 1‐methyl‐2‐pyrrolidinone gave [^14^C]N‐acetylguanine (2). Reaction with 2‐(diethylphosphonomethoxy) ethylmethanesulfonate in N,N‐dimethylformami
9-α-D-Arabinofuranosyl-8-azaadenine-2-14C
✍ Scribed by John A. Montgomery; H. Jeanette Thomas
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 152 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0022-2135
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📜 SIMILAR VOLUMES
The synthesis of t h e title canpound (7) is described. [2-14C] cytosine (I) is treated with an aqueous mixture of sodium bisulfite and sodium sulfate at 8OoC for 30 rnin. The resulting solid is then treated with aqueous sodiun hydroxide and passed through a cation exchange colunn, producing [ Z-14C
## Abstract The synthesis of [^14^C] PMEA (3) was achieved by coupling the sodium salt of 8‐[^14^C]adenine (1) with 2‐(diisopropyl‐phosphonymethoxy) ethanol methanesulfonate in N,N‐dimethylformamide at 100°C to provide the diisopropyl ester (2). Deesterification with bromotrimethylsilane in acetoni
The reaction of [2-14C]-2 ,4-bis-O-(trimethylsilyl)uracil (2) with ~-~-acetyl-~-0-benzoyl-2-deoxy-2-fluoro-~-D-arabinofuranosyl bromide (3) yielded the 3-O-acety1-5-0-benzoyl nucleos e 4 which was hydrolyzed with methanolic ammonia to afford [ 2-feC]-T-( 2-deoxy-2fluoro-p-D-arabinofuranosy1)uracil (
1 4 C-Labelled l-~-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) was synthesized in 26.6% radiochemical yield from 1-R-Darabinofuranosyl-5-formyluracil and '"C-labelled malonic acid for the purpose of the metabolic studies in animals.
Service der Ilol&culer )I.rqu&er CXN-SACLAY 91191 GIF-SUR-WETTE CEDKX M I SIII+UBY I The preparations of 1.~-bcnsiroxaso~e-3-.c.tic acid labelled with 14C in porition a o r B of the ride chain are dercribed. a-14C acid war obtained from 4-hydroxy cormrarin [3-14C] via Prier rearrangewnt of phenyl ac