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9-(2-Phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine (cpr-PMEDAP) as a prodrug of 9-(2-Phosphonylmethoxyethyl)guanine (PMEG)

โœ Scribed by Mindy L Compton; John J Toole; Lisa R Paborsky


Book ID
113994477
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
355 KB
Volume
58
Category
Article
ISSN
0006-2952

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9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) is a broad-spectrum antiviral agent with potent activity against DNA viruses and retroviruses. We now demonstrate that PMEDAP is highly efficacious when given orally to mice infected with either Moloney murine sarcoma virus (MSV), Friend leukem