BMS-200475, a novel carbocyclic 2′-deoxy
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G.S. Bisacchi; S.T. Chao; C. Bachard; J.P. Daris; S. Innaimo; G.A. Jacobs; O. Ko
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Article
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1997
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Elsevier Science
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English
⚖ 297 KB
BMS-200475 , a novel carbocyclic analog of 2'-deoxyguanosine, is a potent inhibitor of hepatitis B virus in vitro (EDs0 = 3 nM) with relatively low cytotoxicity (CC50 = 21-120 pNI). A practical 10-step asymmetric synthesis was developed affording BMS-200475 in 18% overall chemical yield and >99% op