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Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo

✍ Scribed by Lieve Naesens; Jan Balzarini; Erik De Clercq

Book ID
118392445
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
666 KB
Volume
16
Category
Article
ISSN
0166-3542

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## Abstract The present work describes an electrophoretic method for the separation and determination of the new antivirals, 9‐(2‐phosphonylmethoxyethyl)adenine (PMEA) and 9‐(2‐phosphonylmethoxyethyl)‐2,9‐diaminopurine (PMEDAP) in model mixtures with some monoribonucleotide isomers (3′‐AMP, 2′‐CMP,