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879 - Clinical significance of urokinase plasminogen activator and it receptor in breast cancer

✍ Scribed by M.J. Duffy; C. Duggan; T. Maguire; E. McDermott; N. O’Higgins

Book ID
117665123
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
256 KB
Volume
33
Category
Article
ISSN
0959-8049

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Urokinase plasminogen activator and urok
Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer
✍ C. Duggan; T. Maguire; E. McDermott; N. O'Higgins; J. J. Fennelly; M. J. Duffy 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 385 KB 👁 1 views

Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA mediates its action while attached to a membrane-bound receptor (uPAR). In this investigation we show that uPAR levels correlate with uPA levels in human breast cancers. uPAR levels, however, d

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## Abstract The involvement of the urokinase‐type plasminogen activator (uPA) system in particular has been extensively studied in the pathogenesis of cancer. The molecular role of the uPA receptor (uPAR) is well characterized with its participation in cell migration and extracellular matrix (ECM)