836 P16 and P53 levels after different treatments in human tumor cells
✍ Scribed by T. Valenzuela; M.I. Nuñez; E. Siles; M. Villalobos; V. Pedraza; A. Gordon; T.J. McMillan; J.M. Ruiz de Almodóvar
- Book ID
- 116167582
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 161 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0959-8049
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To assess the potential relationship between p53 and p16 proteins in the cellular response to stress, we have examined the levels of these proteins in a series of human tumor cell lines after treatment with either ionizing radiation or hyperthermia. We found that cells with abnormal radiationinduced
## Abstract Mutations in the __p53__ gene are common in many cancers. They have been documented to occur in about 55% of all cancers of 51 different cell and tissue types. These mutations are accompanied by overexpression of the p53 protein in the nucleus of the cell, and this protein has lost its