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Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glioblastoma cells

✍ Scribed by Mahyar-Roemer, Mojgan; Fritzsche, Claudia; Wagner, Sascha; Laue, Michael; Roemer, Klaus


Book ID
110068709
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
369 KB
Volume
23
Category
Article
ISSN
0950-9232

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p2lCipl was first isolated as one of the cyclin-dependent kinase (Cdk) interacting proteins induced by wild-type p53 gene product, and it appears to play an essential regulatory role in the control of cell proliferation as a potent, tight-binding inhibitor of cyclin-Cdk complex that blocks the G,/S