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805 Alterations in BRCA1, BRCA2, TP53 and ATM genes in sporadic breast tumours

✍ Scribed by J. Prokopcova; J. Soukupova; I. Ticha; M. Janatova; J. Sevcik; Z. Kleibl; P. Kleiblova; P. Pohlreich

Book ID
119602581
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
47 KB
Volume
8
Category
Article
ISSN
1359-6349

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Increased frequency of TP53 mutations in
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✍ Susan J. Ramus; Lynda G. Bobrow; Paul D.P. Pharoah; Damon S. Finnigan; Ami Fishm πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 72 KB πŸ‘ 2 views

We screened 81 ovarian tumours (30 BRCA1 associated, 18 BRCA2 associated, and 33 sporadic) for somatic TP53 mutations using both DNA analysis and immunostaining. TP53 mutations were significantly more frequent in tumours with mutations in BRCA1 (70% by immunostaining and 60% by DNA analysis) and BRC