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PP-4-15 BRCA1 Gene alterations in sporadic breast cancer

✍ Scribed by B. Gomendio; E. Garcia; R. Perez-Carrión; A. Moyano; M. Provencio; R. Cubedo; P. España; F. Bonilla


Book ID
116168126
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
181 KB
Volume
32
Category
Article
ISSN
0959-8049

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## Abstract The __BRCA1__ gene was identified and cloned in 1994 based its linkage to early onset breast cancer and breast‐ovarian cancer syndromes in women. While inherited mutations of BRCA1 are responsible for about 40–45% of hereditary breast cancers, these mutations account for only 2‐3% of al