The syntheses of 7-deaza-N6-methyladenine N9-(2'-deoxy-~-o-ribofuranoside) (2) as well as o f 8-aza-7-deaza-N6-methyladenine N8-and N9-(2'-deoxyribofuranosides) (3 and 4, resp.) are described. A 4,4'-dimethoxytritylation followed by phosphitylation yielded the methyl phosphoramidites 12-14. They wer
8-Aza-7-deazaadenine N8- and N8-(β-D-2′-Deoxyribofuranosides): Building blocks for automated DNA synthesis and properties of oligodeoxyribonucleotides
✍ Scribed by Frank Seela; Klaus Kaiser
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- German
- Weight
- 707 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
A', is the symbol used for the 2'-deoxyadenosine moiety with the unusual Ns-instead of the usual fl-glycosidic linkage (purine numbering, see 1). The group Me,N-C(Me)= is represented by m,ma. The differences can also be attributed to the different attacking nucleophile (NH, us. OH-).
📜 SIMILAR VOLUMES
## Abstract Oligonucleotides continuing 3‐deaza‐2′‐deoxyguanosine (I) or its __N__^7^‐regioisomer 2 were prepared by solid‐phase synthesis using P^111^ chemistry. Protection of ^1^ or ^2^ with __N__,__N__ V‐dimethylformamide diethyl acetal followed by 4,4′‐dimethoxytritylation afforded imidazo[4,5‐
The natural and synthetic glucocorticoids are very important compounds commonly used as drugs against many diseases. Recently, we have reported the synthesis of some of the title compounds and their transformations into 6-methyl-5-androstene-3,11,17-trione 3-ethyleneacctal, a building block for the