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Base Pairing of 8-Aza-7-deazapurine-2,6-diamine Linked via the N(8)-Position to the DNA Backbone: Universal Base-Pairing Properties and Formation of Highly Stable Duplexes when Alternating with dT

✍ Scribed by Junlin He; Frank Seela

Publisher: John Wiley and Sons
Year: 2002
Tongue: German
Weight: 167 KB
Volume: 85
Category: Article
ISSN: 0018-019X
DOI: 10.1002/1522-2675(200205)85:5<1340::aid-hlca1340>3.0.co;2-h

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Base-Pairing Properties of 8-Aza-7-deazaadenine Linked via the 8-Position to the DNA Backbone

✍ Frank Seela; Matthias Zulauf; Harald Debelak 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 German ⚖ 346 KB 👁 1 views

The base-pairing properties of oligonucleotides containing the unusual N 8 -linked 8-aza-7-deazaadenine 2'deoxyribonucleoside (2a) as well as its 7-bromo derivative 2b are described. The oligonucleotides were prepared by solid-phase synthesis employing phosphoramidite chemistry. Compound 2a forms a