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8-Aza-7-deaza-2′-deoxyguanosine: Phosphoramidite synthesis and properties of octanucleotides

✍ Scribed by Frank Seela; Hansjürgen Driller


Publisher
John Wiley and Sons
Year
1988
Tongue
German
Weight
489 KB
Volume
71
Category
Article
ISSN
0018-019X

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Oligonucleotides Containing Pyrazolo[3,4
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Oligonucleotides containing 7-substituted 8-aza-7-deazaguanines ( 6-amino-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones) were prepared by automated solid-phase synthesis. A series of 7-alkynylated 8aza-7-deaza-2'-deoxyguanosines (see 4a ± d) were synthesized with the 7-iodonucleoside 3c as starting