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ChemInform Abstract: The α-D Anomer of 5-Aza-7-deaza-2′-deoxyguanosine.

✍ Scribed by Frank Seela; Helmut Rosemeyer; Alexander Melenewski; Eva-Maria Heithoff; Henning Eickmeier; Hans Reuter

Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
33
Category
Article
ISSN
0931-7597

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Oligonucleotides containing 7-substituted 8-aza-7-deazaguanines ( 6-amino-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones) were prepared by automated solid-phase synthesis. A series of 7-alkynylated 8aza-7-deaza-2'-deoxyguanosines (see 4a ± d) were synthesized with the 7-iodonucleoside 3c as starting