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8-Aza-7-deaza-2′,3′-dideoxyguanosine: Deoxygenation of its 2′deoxy-β-D-ribofuranoside

✍ Scribed by Frank Seela; Hansjüegen Driller

Publisher
John Wiley and Sons
Year
1988
Tongue
German
Weight
353 KB
Volume
71
Category
Article
ISSN
0018-019X

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## Abstract Nucleobase‐anion glycosylation of 2‐[(2‐methyl‐1‐oxopropyl)amino]imidazo[1,2‐__a__]‐1,3,5‐triazin‐4(8__H__)‐one (**6**) with 3,5‐di‐__O__‐benzoyl‐2‐deoxy‐2‐fluoro‐__α__‐D‐arabinofuranosyl bromide (**8**) furnishes a mixture of the benzoyl‐protected anomeric 2‐amino‐8‐(2‐deoxy‐2‐fluoro‐D

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Oligonucleotides containing 7-substituted 8-aza-7-deazaguanines ( 6-amino-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones) were prepared by automated solid-phase synthesis. A series of 7-alkynylated 8aza-7-deaza-2'-deoxyguanosines (see 4a ± d) were synthesized with the 7-iodonucleoside 3c as starting