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75Se-labelled bile acid analogues

✍ Scribed by R. Monks; I. L. Thomas

Publisher: John Wiley and Sons
Year: 1983
Tongue: French
Weight: 908 KB
Volume: 20
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580200405

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✦ Synopsis

Abstract

The synthesis of several ^75^Se‐labelled bile acid analogues^*^ is described in which selenium‐75 replaces a carbon methylene group at different positions in the C‐17 side‐chain. Procedures for the synthesis of necessary nonradioactive intermediates are included. Some results for the organ distribution of the compounds in rats are given. 23‐[^75^Se] selena‐25‐homocholic acid and its glycine and taurine conjugates show particularly good properties for the study of the enterohepatic circulation of bile acids.

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