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Labeled bile acids V: Deuterium and carbon-13 labeled cholic, chenodeoxycholic and ursodeoxycholic acids

✍ Scribed by Chee Kong Lai; Chang Yon Byon; Marcel Gut; Danuta Mostowicz; Warren G. Anderson

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
364 KB
Volume
21
Category
Article
ISSN
0022-2135

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✦ Synopsis

This paper describes a general, simple and short procedure for the introduction o f stable isotopes (deuterium and carbon-13) to the side chain of bile acids. The bisnorcholyl aldehydes of cholic and chenodeoxycholic acids are key intermediates, while the isotope is introduced by the Wittig condensation o f [1 ,2-13 C2]-(carbethoxyrnethylene)triphenylphosphorane.

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