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74 Toll-Like Receptor (TLR) 2 in Kupffer Cells Plays a Crucial Role in the Development of Steatohepatitis in Mice

✍ Scribed by Miura, Kouichi; Inokuchi, Sayaka; Ohnishi, Hirohide; Brenner, David A.; Seki, Ekihiro


Book ID
122664871
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
83 KB
Volume
138
Category
Article
ISSN
0016-5085

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## Abstract Severe injury deranges immune function and increases the risk of sepsis and multiple organ failure. Kupffer cells play a major role in mediating posttraumatic immune responses, in part via different Toll‐like receptors (TLR). Although mitogen‐activated protein kinases (MAPK) are key ele