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Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis

✍ Scribed by Chantal A. Rivera; Patrick Adegboyega; Nico van Rooijen; Arlene Tagalicud; Monique Allman; Matthew Wallace

Book ID
116651379
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
986 KB
Volume
47
Category
Article
ISSN
0168-8278

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## Abstract Severe injury deranges immune function and increases the risk of sepsis and multiple organ failure. Kupffer cells play a major role in mediating posttraumatic immune responses, in part via different Toll‐like receptors (TLR). Although mitogen‐activated protein kinases (MAPK) are key ele