72 Restoration of wild-type p53 in malignant melanoma
โ Scribed by D. Weber; J. Markowitz; A. MacKerell; F. Carrier
- Book ID
- 118621256
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 143 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1359-6349
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## Abstract ## Background. In the majority of human cancers, the tumor suppressor activity of p53 is impaired because of mutational events or interactions with other proteins (ie, MDM2). The loss of p53 function is responsible for increased aggressiveness of cancers, while tumor chemoresistance an
Alterations of the p53 tumor suppressor gene are the most frequent genetic abnormalities in human malignancies, but the role of p53 in the etiology of malignant melanomas is unclear. Fifty unselected malignant melanomas were analyzed for p53 overexpression by immunohistochemistry using 3 monoclonal