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7029 CYP17 gene polymorphism in prostate cancer

โœ Scribed by Sivonova, M.; Dobrota, D.; Matakova, T.; Racay, P.; Hatok, J.; Kliment, J.

Book ID
123139778
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
55 KB
Volume
7
Category
Article
ISSN
1359-6349

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CYP17 encodes the enzyme cytochrome P-450c17โฃ, which mediates both 17โฃ-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog