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CYP17 gene polymorphism and prostate cancer susceptibility in a Tunisian population

✍ Scribed by Yousra Souiden; Manel Mahdouani; Kamel Chaieb; Rafik Elkamel; Kacem Mahdouani

Book ID
116332725
Publisher
Elsevier
Year
2011
Tongue
English
Weight
242 KB
Volume
35
Category
Article
ISSN
1877-7821

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CYP17 encodes the enzyme cytochrome P-450c17␣, which mediates both 17␣-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog